In December 2011, InnoCentive partnered with the Foundation for Prader-Willi Research (FPWR) to launch a Challenge seeking novel avenues for research into hyperphagia, or unregulated appetite, common in children with Prader-Willi syndrome. We are pleased to annouce the successful completion of the Challenge along with a video announcement of the winners, as well as provide open access to the actual winning solutions via FPWR's blog.