Please note that the details of this Challenge are no longer open. This challenge is awarded and is no longer accepting new submissions. You can:
Challenge ALS Biomarker
ALS Biomarker
STATUS: Awarded
Active Solvers: 1117
Posted: May 15 2009
Challenge ID: 8305421
Prize4Life Prize 4 Life Discuss this Challenge with other solvers Discuss Share Challenge Share
Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease) is a fatal neurodegenerative disorder characterized by selective death of motor neurons in the brain and spinal cord. This leads to muscle weakness, atrophy, and gradual paralysis. At present, there is no effective therapy for the disease and patients usually die within 2-5 years after the onset of symptoms. In order to accelerate the identification of effective treatments for ALS, a biomarker for measuring disease progression is needed.
Prize4Life is seeking a biomarker for measuring disease progression in Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s Disease). The proposed biomarker should meet the criteria outlined in the Detailed Description & Requirements of the challenge. Up to 1 million USD will be awarded for a validated ALS biomarker capable of being used in Phase II clinical trials to determine treatment efficacy.

Any biological correlate (e.g. body fluids, imaging, electrophysiological examination etc.) can qualify as a solution, as long as the Solver provides a detailed description and validation for it.

There are no specific requirements as to the method by which the Solver delivers a result. As an example, the validation could be based on clinical or experimental work, or on statistical analysis of existing trials data. However, the Solver must provide statistically significant results as proof for the validity of the solution. All biological correlate(s) need to be thoroughly characterized. The Solver's proposal should also be accompanied by a solid scientific rationale supported by literature precedents. If Solvers are facing difficulties getting access to necessary information, they can approach the Seeker. The Seeker will help if he sees fit to do so.

The deadline for this prize is rolling such that submissions will be considered as they are received and, at the discretion of the Seeker, the first submission which meets all of the challenge criteria will be awarded the prize. Unlike many other InnoCentive Seekers, Prize4Life makes no IP claims as to the solution submitted and our IP policy is explained in more detail in the solver agreement.
What is InnoCentive?
InnoCentive is the global innovation marketplace where creative minds solve some of the world's most important problems for cash awards up to $1 million. Commercial, governmental and humanitarian organizations engage with InnoCentive to solve problems that can impact humankind in areas ranging from the environment to medical advancements.

What is an RTP Challenge?

An InnoCentive RTP (Reduction to Practice) Challenge is a prototype that proves an idea, and is similar to an InnoCentive Theoretical Challenge in its high level of detail. However, an RTP requires the Solver to submit a validated solution, either in the form of original data or a physical sample. Also the Seeker is allowed to test the proposed solution. For details about treatment of IP rights, please see the Challenge-Specific Agreement.

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