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Challenge Replacing Ag/AgCl for In-Vivo Reference Electrodes
Replacing Ag/AgCl for In-Vivo Reference Electrodes
STATUS: Awarded
Active Solvers: 174
Posted: Mar 31 2010
Challenge ID: 9314866
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The Seeker wishes to identify conductive materials feasible for use in a reference electrode. The material should be suitable for in vivo physiological measurements.

This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker.
Amperometric electrochemical sensors require a reference electrode to properly control potential during a measurement. One of the most common reference electrode materials for aqueous solutions, particularly physiological solutions, is Ag/AgCl. Release of silver ions (Ag+) during measurement compromises biocompatibility of sensors, making Ag/AgCl undesirable for in-vivo applications.

The Seeker requests alternatives to Ag/AgCl that may be used as a reference electrode in vivo. The material should provide a stable reference potential, and have a low interfacial impedance. The proposed material should be amenable to mass production and to sterilization by irradiation.
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