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Challenge JC Virus or Polyoma Virus Animal Model
JC Virus or Polyoma Virus Animal Model
STATUS: Awarded
Active Solvers: 166
Posted: May 25 2010
Challenge ID: 9435248
 
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Abstract
An animal model is required which allows replication of JC virus. The Seeker requires a theoretical proposal with a detailed strategy how to step-wise develop and test the animal model. A non-human cell-culture/tissue model allowing JC virus replication would also be considered.

Successful Solvers exhibiting sufficient knowledge and ability may be asked to enter a contract research agreement with the Seeker to develop such an animal model. This is a Theoretical Challenge and requires only a pen & paper solution.
Overview
Progressive Multifocal Leukoencephalopathy (PML) is a severe and currently untreatable neurodegenerative disease of humans associated both with infection with the JC Virus and with suppression of the host immune system. JC virus does not replicate in animal tissues. This Challenge requires proposals for strategies to make new animal models that would allow growth of JC virus, or a similar virus, in a non-human host. For this, either the host or the virus may be modified or a chimaeric animal model may be applied.
What is InnoCentive?
InnoCentive is the global innovation marketplace where creative minds solve some of the world's most important problems for cash awards up to $1 million. Commercial, governmental and humanitarian organizations engage with InnoCentive to solve problems that can impact humankind in areas ranging from the environment to medical advancements.

What is a Theoretical-Licensing Challenge?

An InnoCentive Theoretical Challenge builds upon an idea but is not yet a proof of concept. A solution to a Theoretical Challenge will solidify the Solver's concept with detailed descriptions, specifications and requirements necessary to bringing a good idea closer to becoming an actual product or service.

This Challenge is a Theoretical-Licensing Challenge, meaning that the Seeker is requesting non-exclusive rights to use the winning solution. By contrast, Theoretical-IP Transfer means that Solvers must relinquish all rights to the Intellectual Property (IP) for which they are awarded. For these forms of a Theoretical Challenge, Solvers that do not win retain the rights to their solution after the evaluation period is complete. The Seeker retains no rights to any IP not awarded.

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