The non-profit Citrus Research and Development Foundation, desires proposals for RNA sequences that may combat the lethal Citrus Greening Disease (also known as Huanglongbing or HLB) by interfering with the feeding of the Asian Citrus Psyllid or preventing transmission of Candidatus Liberibacter by the Asian Citrus Psyllid. HLB threatens citrus production around the world and since 2005 has spread throughout all of the commercial citrus producing counties in Florida where an estimated 18% or more of the trees are infected.
This is a non-standard Reduction-to-Practice Challenge. The only required deliverable is a written proposal for RNAi sequences targeted against known public gene sequences available here. Awards will be made only after experimental proof-of-concept data has been generated by the Seeker. Due to the nature of the RNAi screening procedure an extended evaluation period of 6-12 months is anticipated.
The Citrus Research and Development Foundation, Inc. are focusing on developing therapies to combat Citrus Greening disease. The causative agent (Candidatus Liberibacter) is transmitted to citrus trees during feeding of the Asian Citrus Psyllid, a sucking pest. Recent work has developed a screening assay to test RNAi approaches to killing the psyllid vector, inhibiting psyllid feeding, or otherwise blocking transmission of the bacterial pathogen Candidatus Liberibacter.
Submissions to this Challenge should include a detailed description of the proposed Solution addressing specific Solution Requirements presented in the Detailed Description of the Challenge. This description should be accompanied by a well-articulated rationale supported, if possible, by literature/patent precedents or experimental data.
The award is contingent upon theoretical evaluation and experimental validation of the submitted Solutions by the Seeker.
To receive an award, the Solvers will have to transfer to the Seeker their exclusive Intellectual Property (IP) rights to the solution. However, the Seeker will be willing to consider a licensingagreement for a partial award if exclusive IP cannot be transferred by the Solver.
An InnoCentive RTP (Reduction to Practice) Challenge is a prototype that proves an idea, and is similar to an InnoCentive Theoretical Challenge in its high level of detail. However, an RTP requires the Solver to submit a validated solution, either in the form of original data or a physical sample. Also the Seeker is allowed to test the proposed solution.