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Male/Female Differences in the Pathogenesis and Presentation of Alzheimer’s Disease in Pre-symptomatic, Early Symptomatic and Late Stages

STATUS: Awarded
ACTIVE SOLVERS: 806
POSTED: Apr 26 2013
SOURCE: InnoCentive

The Geoffrey Beene Foundation Alzheimer’s Initiative (GBFAI) is launching the 2013 Geoffrey Beene Global NeuroDiscovery Challenge whose goal is to identify male/female differences in the pathogenesis and presentation of Alzheimer’s disease (AD) in the pre-symptomatic, early symptomatic and late stages of AD. The objective of this Challenge is to generate novel hypotheses addressing the causes and consequences of such differences. The Solvers are also expected to provide a rationale supported by available data and a detailed research plan describing how to test the hypothesis. Of particular interest are hypotheses that can be validated in a secondary phase by mining existing AD databases for analysis of variables associated with biologic male/female differences in AD.  

This Challenge requires only a written proposal.

 

Challenge ID: 9933328
 
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Challenge Overview

New insights, paradigms and tools are urgently needed to gain a better understanding of the processes associated with the pathogenesis and presentation of Alzheimer’s disease (AD) in both women and men. This new knowledge will not only help reveal the existence of biologic male/female differences at different stages of the disease but will also contribute to a mechanistic understanding of the neurodegenerative cascade in AD. 

To address this need, the Geoffrey Beene Foundation Alzheimer’s Initiative (GBFAI), through the launch of its 2013 Geoffrey Beene Global NeuroDiscovery Challenge, seeks to identify male/female differences in the pathogenesis and presentation of Alzheimer’s disease (AD) in the pre-symptomatic, early symptomatic and late dementia stages because answers may come from looking across the spectrum of the disease.  The objective of this Challenge is to generate novel hypotheses addressing the causes and consequences of such differences. All novel hypotheses related to the topic are encouraged. The Solvers are also expected to provide a rationale supported by available data and a detailed research plan describing how to test the hypothesis.  Of particular interest are hypotheses that can be validated in a secondary phase by mining existing AD databases for analysis of variables associated with biologic male/female differences in AD.  

This is a Theoretical Challenge that requires only a written proposal to be submitted.  The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker. 

To receive an award, the Solvers will not have to transfer their exclusive intellectual property (IP) rights to the Seeker.  Instead, they will grant to the Seeker non-exclusive license to practice their solutions. 

GBFAI and other Challenge Sponsors are extremely interested in further development of one or more of the Winning Solutions after the completion of this Challenge. While interest and ability to implement the Solutions are not required to win an award, Solvers should indicate their interest (or lack thereof) in participating in the follow-up implementation of their proposal (second phase, see below).

What is InnoCentive?

InnoCentive is the global innovation marketplace where creative minds solve some of the world's most important problems for cash awards up to $1 million. Commercial, governmental and humanitarian organizations engage with InnoCentive to solve problems that can impact humankind in areas ranging from the environment to medical advancements.

What is a Theoretical-Licensing Challenge?

An InnoCentive Theoretical Challenge builds upon an idea but is not yet a proof of concept. A solution to a Theoretical Challenge will solidify the Solver's concept with detailed descriptions, specifications and requirements necessary to bringing a good idea closer to becoming an actual product or service.

This Challenge is a Theoretical-Licensing Challenge, meaning that the Seeker is requesting non-exclusive rights to use the winning solution. By contrast, Theoretical-IP Transfer means that Solvers must relinquish all rights to the Intellectual Property (IP) for which they are awarded. For these forms of a Theoretical Challenge, Solvers that do not win retain the rights to their solution after the evaluation period is complete. The Seeker retains no rights to any IP not awarded.

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