The Seeker wishes to incorporate proteins or other biomolecules into an artificial cell or vesicle membrane where their interaction can be studied without the interference of native proteins / molecules, inevitable when using an actual cell. This challenge seeks ideas for how to create an artificial cell / vesicle which will closely resemble that of a native cell and will be able to survive experimentation, including storage, handling, and centrifugation, and which will also allow for incorporation of a water soluble dye which will be released into solution when the cell / vesicle is disrupted or lysed.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Researchers often need to study the interaction between proteins presented on cell surface instead of in the soluble phase. One problem with performing this type of analysis in real cells is the interference of non-specific effects due to other proteins which may interact with the same molecules. For example, a scientist may wish to measure the consequence of antibody binding to a specific cell surface protein, but the antibody may bind to other similar proteins and other proteins may interfere with the antibody initiated effects, making it impossible to attribute the observed effects to the protein of interest. The Seeker wishes to construct artificial vesicles / cells which will allow for incorporation of specific proteins / molecules and also will contain a water soluble dye to be released upon disintegration of the artificial membrane (cell lysis). The solution must produce artificial membranes which are similar in nature to actual cell membranes, will stand up to the rigors of experimentation, and will be cost effective.
This is an Ideation Challenge, which has the following unique features:
Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on October 31, 2014. Late submissions will not be considered.
After the Challenge deadline, the Seeker will complete the review process and make a decision with regards to the Winning Solution(s). All Solvers that submit a proposal will be notified on the status of their submissions; however, no detailed evaluation of individual submissions will be provided.
ABOUT THE SEEKER
Dr. Feng Lin is a research scientist in the Department of Immunology at Cleveland Clinic. His work focuses on immune regulation in autoimmune diseases and transplantation. He is well published and receives grant support from the NIH and other funding agencies.
What is an InnoCentive Ideation™ Challenge?
An InnoCentive Ideation™ Challenge is a broad question formulated to obtain access to new ideas, similar to a global brainstorm for producing a breakthrough idea or market survey which may include ideas for a new product line, a new commercial application for a current product, or even a viral marketing idea to recruit new customers. Ideation™ Challenge submissions are typically about two written pages, and Seekers receive a non-exclusive, perpetual license to use all submissions.
In an Ideation™ Challenge, Solvers may:
Solvers should not reveal any confidential information in their submissions. Often the Ideation™ Challenge will be followed by one or more of the other three Challenge types to further develop the ideas and gain Intellectual Property protection when the concept has been well-defined.