Understanding the different pathways by which prostate cancer cells produce the androgens that drive their growth is important for treating this disease. The development of new therapies would be aided by the ability to monitor metabolite concentrations in these pathways in real time. The Seeker hopes to find a method, which may employ engineered fluorescent proteins or other applicable techniques, to detect the various, similar metabolite molecules with high specificity, in real time and at the single cell level.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Prostate cancer kills more than 20,000 men annually in the United States. Treating advanced prostate cancer involves inhibiting the production of the androgens that drive cell growth. There are multiple pathways that cells may employ, so the ability to monitor these various reactions is important. Real time monitoring of the metabolites in these pathways at the single cell level would lead to a deeper understanding of the processes that drive cancer growth. Because there are eight steroid molecules in the pathways, all with similar structures, detection also requires high specificity. The Seeker desires a method, which may employ engineered fluorescent proteins or other applicable techniques, to detect the various, similar metabolite molecules with high specificity, in real time, and at the single cell level.
This is an Ideation Challenge, which has the following unique features:
Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on October 24, 2014. Late submissions will not be considered.
After the Challenge deadline, the Seeker will complete the review process and make a decision with regards to the Winning Solution(s). All Solvers that submit a proposal will be notified on the status of their submissions; however, no detailed evaluation of individual submissions will be provided.
ABOUT THE SEEKER
Dr Nima Sharifi is a medical oncologist and laboratory scientist at Cleveland Clinic who has spent his career trying to solve how advanced prostate cancer becomes resistant to hormonal therapy and developing new strategies to overcome treatment resistance.
What is an InnoCentive Ideation™ Challenge?
An InnoCentive Ideation™ Challenge is a broad question formulated to obtain access to new ideas, similar to a global brainstorm for producing a breakthrough idea or market survey which may include ideas for a new product line, a new commercial application for a current product, or even a viral marketing idea to recruit new customers. Ideation™ Challenge submissions are typically about two written pages, and Seekers receive a non-exclusive, perpetual license to use all submissions.
In an Ideation™ Challenge, Solvers may:
Solvers should not reveal any confidential information in their submissions. Often the Ideation™ Challenge will be followed by one or more of the other three Challenge types to further develop the ideas and gain Intellectual Property protection when the concept has been well-defined.