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Challenge Comparative Effectiveness Research and Precision Medicine Approaches for Heart Disease & Stroke Treatment
Comparative Effectiveness Research and Precision Medicine Approaches for Heart Disease & Stroke Treatment
STATUS: Awarded
Active Solvers: 196
Posted: Sep 06 2016
Challenge ID: 9933836
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Earlier this year, the American Heart Association (AHA), in partnership with Patient-Centered Outcomes Research Institute (PCORI), conducted a Challenge to hear patients' insights on how health decisions related to heart disease and stroke were made. After patients identified many areas of uncertainty, we are now turning to researchers and clinicians to address several of them through refinement into comparative effectiveness research questions that could benefit from precision medicine approaches. This is an Ideation Challenge with a guaranteed award for four submitters.


A variety of caregivers or patients at risk for different cardiac conditions or stroke responded to our first challenge. They described decisional dilemmas that they along with their clinicians face about how to prevent or manage their condition (see Patient Decisional Dilemmas below). While some situations arise because of inadequate communication, cost, or other barriers, we are interested in defining those in which comparative effectiveness research could provide new knowledge to help individual patients and providers choose the therapeutic options that are best for them. There is an opportunity to win a cash prize of $5,000 for your submission.

We are seeking help from researchers and clinicians to develop scientific questions addressing clinical issues in cardiovascular disease and stroke. These questions will address the concerns of patients and caregivers about how to choose the prevention or treatment options that are best for them. It is our intent that the questions received will be considered for use in the creation of future research opportunities to be announced and co-funded by PCORI and the AHA to support comparative effectiveness research that uses precision medicine approaches.

Comparative effectiveness research (CER) is the direct comparison of the benefits and harms of at least two different existing health care interventions to determine which work best for which patients, in terms of outcomes that matter to patients (“patient-centered outcomes”). This research is performed in real-world populations and settings and informs a specific clinical or policy decision (“decisional dilemma”).

Precision Medicine is the tailoring of medical treatment to the individual characteristics of each patient which includes approaches for disease treatment and prevention that take into account individual variability in genes, environment, and lifestyle.

Responsive and successful submissions will incorporate both approaches. To submit a solution, follow the directions here.

This is an Ideation Challenge, which has the following unique features:

  • There is a guaranteed award. Four submitters will be awarded a cash value of $5,000 each, for a total payout of $20,000. The winners will only be chosen from those who complete all requirements and deliverables properly as determined by AHA and PCORI. 
  • You are not required to transfer exclusive intellectual property rights to AHA and PCORI.  Rather, by submitting a response, you grant to AHA and PCORI a royalty-free, perpetual, and non-exclusive license to use any information included in submitted response.

Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on October 6th, 2016

Late submissions will not be considered. After the Challenge deadline, AHA and PCORI will review the submissions and identify award recipients. Contributors that submit a response will be notified on the status of their submissions. No detailed evaluation of individual submissions will be provided.

DECISIONAL DILEMMAS IDENTIFIED BY PATIENTS FROM OUR PREVIOUS CHALLENGE 9933835 (Heart Disease & Stroke Treatment – Unlocking the Potential Based on Your Experiences)

Patients with the following clinical conditions identified decisional dilemmas during their treatment experience.

  1. Patients with heart failure, due to coronary artery disase and other heart diseases affecting normal heart function.
  2. Individuals that experienced symptoms or evidence of coronary heart disease at a young age.
  3. Patients who have experienced a stroke and wish to prevent a recurrent stroke.
  4. Individuals who experience a stroke with underlying autoimmune conditions such as lupus, rheumatoid arthritis, et cetera for which they have been receiving therapy.
  5. Elderly individuals with aortic stenosis.
  6. Parents or Caregivers with Newborns with Congenital Heart disease, including Total Anomalous Pulmonary Venous Return.
  7. Patients with atrial arrhythmias; including those with atrial fibrillation and atrial tachycardias.


What is InnoCentive?
InnoCentive is the global innovation marketplace where creative minds solve some of the world's most important problems for cash awards up to $1 million. Commercial, governmental and humanitarian organizations engage with InnoCentive to solve problems that can impact humankind in areas ranging from the environment to medical advancements.

What is an InnoCentive Ideation™ Challenge?

An InnoCentive Ideation™ Challenge is a broad question formulated to obtain access to new ideas, similar to a global brainstorm for producing a breakthrough idea or market survey which may include ideas for a new product line, a new commercial application for a current product, or even a viral marketing idea to recruit new customers. Ideation™ Challenge submissions are typically about two written pages, and Seekers receive a non-exclusive, perpetual license to use all submissions.

In an Ideation™ Challenge, Solvers may:

  • Submit ideas of their own
  • Submit third party information that they have the right to use and further the authority to convey that right and the right to use and develop derivative works to Seekers
  • Submit information considered in the public domain without any limitations on use

Solvers should not reveal any confidential information in their submissions. Often the Ideation™ Challenge will be followed by one or more of the other three Challenge types to further develop the ideas and gain Intellectual Property protection when the concept has been well-defined.

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