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Challenge Accurate Measurement of Free Drug Concentrations

Accurate Measurement of Free Drug Concentrations

Award: $25,000 USD
Deadline: Withdrawn
Active Solvers: 210
Posted: Feb 22 2017
Challenge ID: 9933901
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The drug discovery process is driven by a series of in vitro and in vivo assays to inform the optimization of drug candidates with the ultimate goal of achieving therapeutic efficacy. The percent of total drug present that is not bound to proteins or other cellular components (i.e., the free drug concentration) is thought to correlate with a compound’s pharmacological activity. Therefore, the Seeker is searching for a novel, non-destructive approach for the precise and accurate measurement of free drug concentrations in target tissues.

This Theoretical Challenge requires only a written proposal.


Selecting compounds for advancement depends largely on the ability to predict the clinical efficacy of a drug based upon its performance in vitro. Molecules that demonstrate high protein binding will have lower amounts of free drug in solution, and thus, a decreased likelihood of interacting with the intended therapeutic target. Therefore, the Seeker is searching for a novel, non-destructive approach for the precise and accurate measurement of free drug concentrations in target tissues.

Although this is a Theoretical Challenge that requires only a written proposal to be submitted – a prototype model or preliminary data is encouraged. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker.

To receive an award, the Solvers will not have to transfer their exclusive IP rights to the Seeker. Instead, Solvers will grant to the Seeker a non-exclusive license to practice their solutions. 

Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on April 22, 2017. 

Late submissions will not be considered.

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InnoCentive is the global innovation marketplace where creative minds solve some of the world's most important problems for cash awards up to $1 million. Commercial, governmental and humanitarian organizations engage with InnoCentive to solve problems that can impact humankind in areas ranging from the environment to medical advancements.

What is a Theoretical-Licensing Challenge?

An InnoCentive Theoretical Challenge builds upon an idea but is not yet a proof of concept. A solution to a Theoretical Challenge will solidify the Solver's concept with detailed descriptions, specifications and requirements necessary to bringing a good idea closer to becoming an actual product or service.

This Challenge is a Theoretical-Licensing Challenge, meaning that the Seeker is requesting non-exclusive rights to use the winning solution. By contrast, Theoretical-IP Transfer means that Solvers must relinquish all rights to the Intellectual Property (IP) for which they are awarded. For these forms of a Theoretical Challenge, Solvers that do not win retain the rights to their solution after the evaluation period is complete. The Seeker retains no rights to any IP not awarded.

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