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Challenge AstraZeneca Challenge: Molecular Strategies to Minimize Off-Target Toxicities of Antibody Drug Conjugates

AstraZeneca Challenge: Molecular Strategies to Minimize Off-Target Toxicities of Antibody Drug Conjugates

Award: $15,000 USD
STATUS: Under Eval
Active Solvers: 217
Posted: Jul 30 2019
Challenge ID: 9934068
 
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Abstract

An antibody-drug conjugate (ADC) is comprised of an antibody connected to a cytotoxic agent with a linker. ADCs are designed to selectively target tumors via binding to specific markers found on the cell surface. Although many ADCs are in clinical development, only a few are FDA approved. To improve the efficacy of ADCs in the treatment of cancer, the Seeker is looking for innovative molecular strategies to minimizing off-target toxicities of ADCs.

This is an Ideation Challenge with a guaranteed award for at least one submitted solution.

Overview

The therapeutic activity of ADCs depends on recognition of the cell surface target antigen, internalization of the ADC upon target binding, and release of the cytotoxic agent within the cell. Off-target binding of the ADCs results in limited efficacy and unwanted toxicities. The Seeker calls for new molecular (i.e. antibody engineering) and chemical (e.g. linker design, tumor restricted release mechanisms, pro-drug approaches) strategies for creating ADCs that are solely active at the tumor site or at the tumor microenvironment thus minimizing off-target toxicities.

This is an Ideation Challenge, which has the following unique features:

  • There is a guaranteed award. The award(s) will be paid to the best submission(s) as solely determined by the Seeker. The total payout will be $15,000, with at least one award being no smaller than $5,000 and no award being smaller than $2,000.
  • The Solvers are not required to transfer exclusive intellectual property rights to the Seeker. Rather, by submitting a proposal, the Solver grants to the Seeker a royalty-free, perpetual, and non-exclusive license to use any information included in this proposal, including for promotional purposes.

Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on September 30, 2019. 

Late submissions will not be considered.

After the Challenge deadline, the Seeker will complete the review process and make a decision with regards to the Winning Solution(s). All Solvers that submit a proposal will be notified on the status of their submissions; however, no detailed evaluation of individual submissions will be provided.

 

ABOUT THE SEEKER

AstraZeneca is a global, science-led, biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines, primarily for the treatment of disease in three main therapy areas – Oncology, Cardiovascular & Metabolic Diseases and Respiratory. AstraZeneca also is selectively active in the areas of autoimmunity, neuroscience and infection. As an innovation-driven, research organization, AstraZeneca recognizes that great ideas come from many sources. Open innovation is an avenue by which ideas can be shared and AstraZeneca recently launched a pavilion to further its commitment to facilitate the advancement of pharmaceutical research.

What is InnoCentive?
InnoCentive is the global innovation marketplace where creative minds solve some of the world's most important problems for cash awards up to $1 million. Commercial, governmental and humanitarian organizations engage with InnoCentive to solve problems that can impact humankind in areas ranging from the environment to medical advancements.

What is an InnoCentive Ideation™ Challenge?

An InnoCentive Ideation™ Challenge is a broad question formulated to obtain access to new ideas, similar to a global brainstorm for producing a breakthrough idea or market survey which may include ideas for a new product line, a new commercial application for a current product, or even a viral marketing idea to recruit new customers. Ideation™ Challenge submissions are typically about two written pages, and Seekers receive a non-exclusive, perpetual license to use all submissions.

In an Ideation™ Challenge, Solvers may:

  • Submit ideas of their own
  • Submit third party information that they have the right to use and further the authority to convey that right and the right to use and develop derivative works to Seekers
  • Submit information considered in the public domain without any limitations on use

Solvers should not reveal any confidential information in their submissions. Often the Ideation™ Challenge will be followed by one or more of the other three Challenge types to further develop the ideas and gain Intellectual Property protection when the concept has been well-defined.

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