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Challenge Novel Method to Monitor Intracellular Trafficking

Novel Method to Monitor Intracellular Trafficking

STATUS: Awarded
Active Solvers: 101
Posted: Jul 09 2018
Challenge ID: 9934108
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Receptor-mediated endocytosis is a process that allows certain molecules to be ingested and absorbed by the cell. The Seeker desires innovative solutions that allow monitoring of internalization and intracellular trafficking of molecules to various subcellular compartments (e.g. endosome, lysosome, etc.) and cytoplasm.

This is an Ideation Challenge with a guaranteed award for at least one submitted solution.


There are various ways developed to monitor subcellular localization of molecules such as monitoring co-localization with various markers using immunofluorescence or using pH-sensitive dyes to trace movement of molecules inside the cells. However, there are still challenges for quantitative analysis of distribution and compartmentalization of molecules in living cells. Therefore, the Seeker desires proposals for innovative experimental methods that can be used to monitor internalization and intracellular trafficking of molecules to various subcellular compartments (e.g. endosome, lysosome, etc.) and cytoplasm.

This is an Ideation Challenge, which has the following unique features:

  • There is a guaranteed award.  The award(s) will be paid to the best submission(s) as solely determined by the Seeker. The total payout will be $10,000, with at least one award being no smaller than $5,000 and no award being smaller than $2,000.
  • The Solvers are not required to transfer exclusive intellectual property rights to the Seeker.  Rather, by submitting a proposal, the Solver grants to the Seeker a royalty-free, fully paid, perpetual, worldwide and non-exclusive license, with the unrestricted right to sublicense through multiple tiers, to make, have made, use, offer to sell, sell, import, display, transfer and otherwise exploit any inventions or information included in the Solver’s submission, including but not limited to commercial and promotional purposes.

Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on August 9, 2018. 

Late submissions will not be considered.

After the Challenge deadline, the Seeker will complete the review process and make a decision with regards to the Winning Solution(s). All Solvers that submit a proposal will be notified on the status of their submissions; however, no detailed evaluation of individual submissions will be provided.

What is InnoCentive?
InnoCentive is the global innovation marketplace where creative minds solve some of the world's most important problems for cash awards up to $1 million. Commercial, governmental and humanitarian organizations engage with InnoCentive to solve problems that can impact humankind in areas ranging from the environment to medical advancements.

What is an InnoCentive Ideation™ Challenge?

An InnoCentive Ideation™ Challenge is a broad question formulated to obtain access to new ideas, similar to a global brainstorm for producing a breakthrough idea or market survey which may include ideas for a new product line, a new commercial application for a current product, or even a viral marketing idea to recruit new customers. Ideation™ Challenge submissions are typically about two written pages, and Seekers receive a non-exclusive, perpetual license to use all submissions.

In an Ideation™ Challenge, Solvers may:

  • Submit ideas of their own
  • Submit third party information that they have the right to use and further the authority to convey that right and the right to use and develop derivative works to Seekers
  • Submit information considered in the public domain without any limitations on use

Solvers should not reveal any confidential information in their submissions. Often the Ideation™ Challenge will be followed by one or more of the other three Challenge types to further develop the ideas and gain Intellectual Property protection when the concept has been well-defined.

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