Receptor-mediated endocytosis is a process that allows certain molecules to be ingested and absorbed by the cell. The Seeker desires innovative solutions that allow monitoring of internalization and intracellular trafficking of molecules to various subcellular compartments (e.g. endosome, lysosome, etc.) and cytoplasm.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
There are various ways developed to monitor subcellular localization of molecules such as monitoring co-localization with various markers using immunofluorescence or using pH-sensitive dyes to trace movement of molecules inside the cells. However, there are still challenges for quantitative analysis of distribution and compartmentalization of molecules in living cells. Therefore, the Seeker desires proposals for innovative experimental methods that can be used to monitor internalization and intracellular trafficking of molecules to various subcellular compartments (e.g. endosome, lysosome, etc.) and cytoplasm.
This is an Ideation Challenge, which has the following unique features:
Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on August 9, 2018.
Late submissions will not be considered.
After the Challenge deadline, the Seeker will complete the review process and make a decision with regards to the Winning Solution(s). All Solvers that submit a proposal will be notified on the status of their submissions; however, no detailed evaluation of individual submissions will be provided.
What is an InnoCentive Ideation™ Challenge?
An InnoCentive Ideation™ Challenge is a broad question formulated to obtain access to new ideas, similar to a global brainstorm for producing a breakthrough idea or market survey which may include ideas for a new product line, a new commercial application for a current product, or even a viral marketing idea to recruit new customers. Ideation™ Challenge submissions are typically about two written pages, and Seekers receive a non-exclusive, perpetual license to use all submissions.
In an Ideation™ Challenge, Solvers may:
Solvers should not reveal any confidential information in their submissions. Often the Ideation™ Challenge will be followed by one or more of the other three Challenge types to further develop the ideas and gain Intellectual Property protection when the concept has been well-defined.