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Challenge Corteva AgriscienceTM Challenge: Seeking Natural Products or Natural Product-Derived Small Molecules

Corteva AgriscienceTM Challenge: Seeking Natural Products or Natural Product-Derived Small Molecules

Award: varies
STATUS: Under Eval
Active Solvers: 110
Posted: Jun 13 2019
Challenge ID: 9934237
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Corteva AgriscienceTM is seeking pure natural products and semi-synthetic natural products for pest control. Material supply of compounds which are natural products or natural-product derived small molecules is desired. Crude extracts and mixtures are not requested for this Challenge.

Intellectual Property:  In return for the Initial Transfer Fee of USD $150 per compound (see further details of the Challenge), you are expected to grant the Seeker only a non-exclusive license to test your compound(s) in their in-house assays and/or use the compound(s) to prepare other compounds for in-house testing.


The discovery of novel modes of action for use in crop protection remains an ongoing challenge for multiple reasons, including the increasing demand for higher protein diets, evolution of resistance to existing solutions, and regulatory and societal pressures to continually improve the safety and toxicological profiles of crop protection chemicals.  Because bacteria, plants, insects and fungi are in a continual evolutionary and ecological battle in the environment, each species develops its own methods for survival.  Some of these tools include the production of small molecules that are generated for a very specific purpose.  As farmers seek to find new crop protection solutions to reduce fungal, insect and weed impact on crop yields, there is an opportunity to explore the use of these small molecules developed by nature to improve agriculture.

As the leader in Natural Products Discovery, Corteva AgriscienceTM has historically discovered and developed a number of natural products and semi-synthetic natural products for pest control.  However, this discovery process of molecules with novel modes of action is an ongoing challenge in the agricultural industry, and as such we are seeking input from the broader scientific community to gain access to more chemical space; in particular, the biologically relevant space that natural products are known to occupy.

Material supply of compounds which are natural products or natural-product derived small molecules is desired.  Crude extracts and mixtures are not requested for this Challenge. Compounds will be strictly filtered for those which adhere to the desired Solution Requirements described in the Detailed Description section of the Challenge.  The Seeker intends to award multiple Solvers for each of their qualifying submissions. 

Intellectual Property

  • In return for the Initial Transfer Fee, you are expected to grant the Seeker a non-exclusive license to use your compound for Seeker’s internal, research purposes (for example, researching the molecule’s properties or preparing derivatives of the molecule). The Initial Transfer Fee will be USD $150 per 2 mg sample of any compound requested by Seeker plus reasonable shipping expenses. For any additional 2 mg sample (including re-supply requests) that the Solver provides at Seeker’s request, the Seeker will pay USD $50. The Seeker will not request (or pay for) a total amount higher than 10 mg per compound (max payment would be $350).
  • The Challenge Specific Agreement (CSA) does, however, require that you do not disclose the structures of any molecules requested by the Seeker to the public or to any third party for a period of 180 days after delivery of the compound(s) to the Seeker.  In this time, the Seeker will test your molecule(s) to determine if they desire exclusive rights to the molecule(s), for which they will pay you a Secondary Award. Please read the CSA and if there are any questions contact us via your project room.

By the deadline, Solvers are requested to provide a list of structures which meet the Solution Requirements listed in the Detailed Description of the Challenge. For the structures that are selected by the Seeker, the Solver shall then send in material samples along with documentation including further details as specified in the Detailed Description. 

This Challenge is targeting Solvers who: 

  • have matching compounds already made (on the shelf), or;
  • are ready to isolate/synthesize matching compounds within the provided timelines. 

This Challenge provides Solvers with a three-month time period for preparing the selected compounds after the deadline of the Challenge.

Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on August 12, 2019. 

Late submissions will not be considered.


Corteva Agriscience™ is the only major agriscience company completely dedicated to agriculture. By combining the strengths of DuPont Pioneer, DuPont Crop Protection and Dow AgroSciences, we've harnessed agriculture's brightest minds and expertise gained over two centuries of scientific achievement. Corteva Agriscience provides growers around the world with the most complete portfolio in the industry — including some of the most recognized brands in agriculture: Pioneer®, Granular®, the newly launched Brevant™ seeds, as well as award-winning Crop Protection active ingredients like Spinosad and Spinetoram — while bringing new products to market through our solid pipeline of active chemistry and technologies. More information can be found at

What is InnoCentive?
InnoCentive is the global innovation marketplace where creative minds solve some of the world's most important problems for cash awards up to $1 million. Commercial, governmental and humanitarian organizations engage with InnoCentive to solve problems that can impact humankind in areas ranging from the environment to medical advancements.

What is an RTP Challenge?

An InnoCentive RTP (Reduction to Practice) Challenge is a prototype that proves an idea, and is similar to an InnoCentive Theoretical Challenge in its high level of detail. However, an RTP requires the Solver to submit a validated solution, either in the form of original data or a physical sample. Also the Seeker is allowed to test the proposed solution. For details about treatment of IP rights, please see the Challenge-Specific Agreement.

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