Protection of Biological Molecules to Enable Delivery Within the Gastrointestinal Tract
As part of the search for alternatives to antibiotics and other novel therapeutics, there is interest in the potential oral application of biological molecules (i.e. peptides & proteins) for activity in the gastrointestinal (GI) tract. One hurdle preventing the oral application of biological molecules is the instability caused by gastric and digestive conditions such as low pH and protease activity encountered in the stomach and intestines. Likewise, high heat and environmental conditions also have negative impacts on the stability of biological molecules. Therefore, the Seeker desires novel approaches to protect biological molecules in order to enable their application in the GI tract.
This Theoretical Challenge requires only a written proposal.
Source: InnoCentive Challenge ID: 9933917
Sanofi Challenge: Novel Targets in Drug Discovery
Patients who have a chronic disease live with the hope that better treatments will be available to manage their symptoms or to cure their condition. The research and development of new medicines is a lengthy process fraught with pitfalls and high costs. We need to enrich the pipeline of early discovery targets that have significant potential for success. Sanofi, a Top 5 global pharmaceutical company, desires partners to find and develop novel research targets in the areas of cardiovascular disease, immunology, and neuroscience.
This is an electronic Request-for-Partners (eRFP) Challenge; the Solver will only need to submit a written proposal to be evaluated by the Seeker with the goal of establishing a collaborative partnership.
Source: InnoCentive Challenge ID: 9933672
Viridis Learning Challenge: New Approaches to Improve Employment Outcomes from Career and Technical Education
Career and technical education (CTE) is a term used to describe schools, institutions, and programs that specialize in the applied sciences, modern technologies, skilled trades, and career preparation. Also known as vocational education programs, students are offered opportunities to gain work experience and job-specific skills while also taking traditional academic courses. CTE is just one of many pathways to success, yet employers are still finding it difficult to identify qualified individuals to hire. Viridis Learning believes that stakeholders must be brought together to share data and automate recruitment of candidates each with verified (or verifiable) knowledge, skills, and ability. Thus, they seek new approaches and insights to better address the nation’s skills gap.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Source: InnoCentive Challenge ID: 9933845
How to Eliminate Delamination of Carton Board During Printing Processes?
Delamination occurs when there is a detachment of the top layer or coating layer of carton board and can be seen after the printing step in the form of bubbles on the carton board surface or a large scale detachment of the carton board cover layer – when this happens, the product is downgraded to waste.
The Seeker is looking for strongly effective methods to eliminate the risk of delamination of the cartonboard during printing processes.
This is a Reduction-to-Practice Challenge that requires submission of written documentation. The Seeker will perform experimental validation of proposed solutions in order to determine the award.
Source: InnoCentive Challenge ID: 9933974
Devices for In-field Characterisation of Non-hazardous Solid Waste
Physico-chemical characterisation of some crucial waste parameters is not possible outside the laboratory environment. However, being able to do it would constitute a significant leap forward in waste management. Therefore, the Seeker is interested in technologies that would allow to rapidly and reliably perform this task in the field.
Source: InnoCentive Challenge ID: 9933863
Improving Patient Compliance in Acne Trials
In clinical trials, patient compliance with taking/applying medication is extremely important. In Acne vulgaris trials, medication is typically applied 1 or 2 times a day over an extended period (e.g., ~12 weeks) which may make 100% compliance difficult to achieve. The Seeker is looking for ideas/methods to improve compliance in acne trials.
Source: InnoCentive Challenge ID: 9933945
Indirect Estimates of Reservoir Water Storage
Water storage in reservoirs behind dams is a vital component for water management, and the amount available defines the delivery of benefits from reservoirs. Available water storage, over time, decreases as sediment deposition occurs, thus decreasing the capacity for storage. This sediment deposition, known as sedimentation, also adversely affects reservoir infrastructure operation and maintenance such as outlet works and water intakes. Assessing the loss of storage capacity currently is an expensive and time consuming process performed directly by in-field surveys.
The Bureau of Reclamation, in collaboration with the U.S. Army Corps of Engineers, is seeking a cost effective method to indirectly estimate the storage capacity and/or sediment volume (storage loss) in reservoirs.
This is a Reduction-to-Practice Challenge that requires written documentation, source code, and delivery of an executable application.
Challenge Orientation Video
Subject matter experts from the Bureau of Reclamation and U.S. Army Corps of Engineers have provided this short video discussing the problem of sediment accumulation and the resulting loss of water reservoir storage capacity:
This web site is hosted by a private entity and is not a service of the Bureau of Reclamation or the Department of the Interior (DOI). The solicitation and collection of your personal or individually identifiable information is subject to the host’s privacy and security policies and will not be shared with Reclamation or DOI unless you win the Challenge. Challenge winners’ personally identifiable information must be made available to Reclamation in order to collect an award. Please consult the Challenge Specific Agreement.
This Challenge is being conducted by the Seeker under the authority of 15 USC 3719, as amended, which states that cash prize purse awards for this Prize Competition may only be given to an individual that is a citizen or permanent resident of the United States, or an entity that is incorporated in and whose primary place of business is in the United States, subject to verification by the Seeker before Prizes are awarded.
However, submissions can be entertained from all Solvers regardless of whether they are U.S. citizens/entities. Meritorious submissions from non-eligible persons and entities, if any, will be recognized in publications issued by the Seeker announcing the results of the competition, such as press releases. Non-U.S citizens/permanent residents or non-U.S entities can also be included on U.S. teams and are eligible to receive non-cash prize awards, if any. However, cash prize purses will only be awarded to persons and entities eligible to receive cash prize purses under the authority of 15 USC 3719, as amended.
Full eligibility details and other restrictions are detailed in the Challenge Specific Agreement.
Source: InnoCentive Challenge ID: 9933766
Accurate Measurement of Free Drug Concentrations
The drug discovery process is driven by a series of in vitro and in vivo assays to inform the optimization of drug candidates with the ultimate goal of achieving therapeutic efficacy. The percent of total drug present that is not bound to proteins or other cellular components (i.e., the free drug concentration) is thought to correlate with a compound’s pharmacological activity. Therefore, the Seeker is searching for a novel, non-destructive approach for the precise and accurate measurement of free drug concentrations in target tissues.
Source: InnoCentive Challenge ID: 9933901
Roche Diabetes Care Challenge
More than 29 million Americans live with diabetes, a metabolic disorder that is characterized by insufficient production or inadequate utilization of insulin resulting in abnormal fluctuations in blood glucose. For diabetics, self-monitoring of blood glucose is essential for knowing when to make therapy adjustments. In the United States, the blood glucose monitoring industry has experienced a negative growth trend despite an increasing number of patients with diabetes. Roche is looking for innovative ideas and solutions that may help a traditional blood glucose manufacturer, like Roche, reverse this trend while meeting patient needs.
Source: InnoCentive Challenge ID: 9933981
Converting Heat Contained in Waste Water Effluents into Forms of Energy for On-site Use
The Seeker is looking to identify processes that can cost-effectively convert the heat contained in hot waste water effluents into forms of energy that can be used to power on-site operations.
Source: InnoCentive Challenge ID: 9933862