Bringing a new pharmaceutical to market is a long, expensive, and complex process that encompasses research, development, approval, and commercialization. Many promising drug candidates fail in the clinic due to shortcomings in their efficacy, safety, or tolerability. Advances have been made to mitigate these issues and these include the identification of translational biomarkers, improvements in finding and optimization of small molecules or antibodies as established therapeutic modalities, and the use of more predictive models reflecting novel disease concepts. These strategies are effective, yet they might not lead to the next breakthrough therapy. Therefore, Boehringer Ingelheim (the Seeker) is looking one step further to find novel therapeutic modalities that have the potential to modulate targets of human disease including such that are usually not amenable by established modalities. Thus, Boehringer Ingelheim (the Seeker) desires partners to find and develop emerging modalities that have high potential to treat or modulate human disease.
This is an electronic Request-for-Partners (eRFP) Challenge; the Solver will only need to submit a written proposal to be evaluated by Boehringer Ingelheim with the goal of establishing a collaborative partnership.
Source: InnoCentive Challenge ID: 9933874
Currently, it is possible to process high starch to protein ratio food like corn, rice and wheat to expand and “puff-up” the material to make a crunchy texture in a shape similar to the original. These processes do not work on low starch to protein ratio, more dense, high fiber and oily food materials like seeds and nuts. The Seeker would like to find processes that could accomplish this expansion on such more nutritious foods that are relatively higher in protein, fiber and fat than commonly expandable starchy grains and seeds.
This Theoretical Challenge requires only a written proposal.
Source: InnoCentive Challenge ID: 9933813
Aluminum sulfate Al2(SO4)3 is used as a coagulant in a water treatment process to obtain clarified water. The clarified water is further directed to demineralization (for feed boilers). While aluminum sulfate is effective in achieving the desired result, its use is associated with unacceptably high aluminum content in wastewater (> 0.04 mg/dm3 soluble aluminum). The Seeker for this Challenge is looking for an effective coagulant/process to cost-effectively treat the water without the negative side effect of high aluminum content in the effluent water.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Source: InnoCentive Challenge ID: 9933875
The Seeker is looking for an alternative humectant than those traditionally used in the food industry. They need materials and processes to be food safe. Ingredients would be preferably natural and considered “clean label”.
Source: InnoCentive Challenge ID: 9933814
Current methods to recover sulfates from wastewater streams are limited in their capability to work in challenging industrial conditions and/or to generate a new revenue stream from the recovered sulfates. Hence, SUEZ is looking for a solution to solve these two limitations.
Source: InnoCentive Challenge ID: 9933861
GSK and Save the Children are committed to working together to help save the lives of one million children. As part of the global partnership between GSK and Save the Children, we are pleased to announce the launch of the fourth annual Healthcare Innovation Award which will provide USD$ 1 million to reward organisations practicing innovative approaches for increasing and improving access to healthcare for children who are the hardest to reach. The organisations judged to extend the reach of health systems in the most innovative and effective ways will be eligible for an Award of up to USD$ 400,000.
Eligible innovative organisations can come from the non-profit, private or public sector, if both the organisation and the innovation are from the developing world. Nominations can be submitted by the organisation themselves, or an organisation may be nominated by a third-party organisation or individual, through a brief questionnaire found within the detailed guidelines.
Source: InnoCentive Challenge ID: 9933899
Acne is a skin condition that is estimated to affect nearly 10% of people worldwide. Since the skin is highly visible to others, people with acne often suffer low self-esteem because of their appearance. Although treatments are available, patients struggle with demanding dosing regimens and low levels of efficacy, especially those with moderate to severe acne. Therefore, the Seeker is looking for novel treatment approaches to improve acne patients’ lives.
Source: InnoCentive Challenge ID: 9933873
Most government facilities utilize a dual door entry system where once a person enters the exterior door they must wait for it to close and lock before the interior door is open. This system prevents unauthorized personnel from “tail gaiting” authorized personnel to gain access to a building. This access control system is known as a “man trap, sally port, or access control vestibule” and is highly effecting in increasing a buildings security. To further increase protection to higher risk facilities Forced Entry, Ballistic Resistant (FE/BR) doors are utilized to harden the access control vestibule. These FE/BR doors can weigh up to 600 lbs. and are installed to mitigate effects of ballistic, manual, and in some cases explosive attacks.
The doors on either side of the access control vestibule (see figure 1) are affected by the air pressure inside room. When one of the two doors are opened an increase in air pressure occurs inside the vestibule and sometimes prevents the open door from closing in a timely manner or latch correctly. This not only increases the time for unauthorized personnel to gain access to the doors, but could increase the effects of an explosive blast on the exterior of the building. A reverse issue is a decrease in air pressure can occur when a door is opened and causes the doors configured in the vestibule to slam shut. HVAC can also affect the pressure inside the vestibule make doors harder to open.
This Challenge is looking for a system or modification that will mitigate the change in air pressure (increase and decrease) to allow the FE/BR doors to properly shut and latch, open within force standards, and close at a safe speed when configured in an access control vestibule. This system or modification can’t reduce the FE/BR door’s or surrounding wall’s ability to mitigate attacked manual, ballistic, or explosive attacks.
Source: InnoCentive Challenge ID: 9933553
People with dentures regularly need to clean them. Despite a number of products available off-the-shelf, this is a cumbersome and user-unfriendly procedure, as it is often time consuming and involves several tasks such as rinsing, brushing, and soaking in solutions.
The Seeker to this Challenge is looking to improve the consumer experience during denture cleaning and is seeking novel cleansers formats that are more consumer-friendly but still highly efficient.
This Challenge requires only a written proposal.
Source: InnoCentive Challenge ID: 9933825
Health and education are essential for the economic development of society. In spite of differences created by geography or demographics, education is highly correlated with not only life span, but also economic growth. An educated worker is more productive and as a parent will make better choices and provide more opportunities for their children to succeed. Research in the developing world indicates that educational status (especially of the mother) is a predictor of health outcomes. Much more can be done, especially in context of the developing countries as every minute, many women and children are dying from preventable diseases and treatable conditions. Therefore, Ideagen seeks to empower women & girls through new approaches that increase access to quality education and / or promoting their good health and well being.
Source: InnoCentive Challenge ID: 9933842