Nearly 3 million people in the United States and 65 million people worldwide have epilepsy, a neurological condition which affects the nervous system and causes seizures. One in 26 people will develop epilepsy at some point in their lifetime, with 150,000 new cases annually in the United States. Nearly 80% of the people with epilepsy live in low- and middle-income countries and three-quarters of these individuals do not get the treatment they need.
Among those living with epilepsy, nearly one-third have ongoing seizures despite existing therapies. Each year, more than 1 out of 1,000 people with epilepsy die from sudden unexpected death in epilepsy (SUDEP). If seizures are uncontrolled, the risk of SUDEP increases to more than 1 out of 150. SUDEP is the leading cause of death in young adults with uncontrolled seizures.
In order to accelerate the identification of effective treatments for SUDEP, the Epilepsy Foundation SUDEP Institute is sponsoring a Reduction to Practice Challenge to develop a predictive biomarker or panel of biomarkers to identify people at risk for SUDEP or seizures that compromise cardiac or respiratory function. The biomarker(s) must serve as an endpoint or surrogate endpoint that will drive human SUDEP interventions. For example, the biomarker(s) may identify a high risk patient group that could be used to test existing candidate interventions such as seizure detection devices.
Milestone 1 requires a detailed Project Plan of the proposed solution. Milestone 2 involves the production of proof-of-concept data. Milestone 3 requires results that demonstrate the predictive efficacy of the biomarker(s). The SUDEP Institute intends to make up to 10 awards from a total award pool of $100,000 for Milestone 1, up to 4 awards of $25,000 each for Milestone 2, and a final award at least $800,000 for successful completion of Milestone 3.
Solvers are encouraged to enter this Challenge even if they were not involved in The SUDEP Institute Challenge: Predictive Biomarkers of Epilepsy – Challenge 9933719. Participants from the previous Challenge may elect to expound upon their (winning) solution or pursue another idea. Solvers should note that the Center for SUDEP Research (CSR) is an NIH-funded research collaborative studying animal models of SUDEP and epilepsy patients who may be at high risk for SUDEP. Solvers may contact the CSR at firstname.lastname@example.org to request data and/or biospecimens to be used in the execution of a Solution. Other resources that Solvers may access are through the North American SUDEP Registry and the Center for Disease Control and Prevention (CDC) Sudden Death in the Young Registry.
This is a Reduction to Practice Challenge that requires written documentation, experimental proof-of-concept data, and biomarker validation data.
Source: InnoCentive Challenge ID: 9933784
The gastrointestinal (GI) tract is the system of organs by which food is ingested and digested, nutrients are absorbed, and waste products are eliminated. GI cell proliferation is essential for maintaining normal physiological function and integrity of the protective epithelial barrier, however, as many GI cells turn over at a rapid rate, normal function and barrier maintenance are highly sensitive to toxic insults. When drug-induced GI toxicity occurs, either by cytotoxicity, inhibition of cell proliferation, or adverse pharmacological effect on receptors and enzymes, damage manifests with a variety of clinical symptoms including nausea, vomiting, ulceration, and diarrhea. It is essential to understand and minimize these consequences, thus AstraZeneca seeks a translationally relevant in vitro model to investigate gastrointestinal toxicity onset and recovery.
This is a Reduction-to-Practice Challenge that requires written documentation, experimental proof-of-concept data, and validation results.
Source: InnoCentive Challenge ID: 9933828
The Bureau of Reclamation, in collaboration with the U.S. Army Corps of Engineers, State of Colorado Department of Natural Resources Dam Safety Branch, and various water irrigation districts that operate federal canals, is seeking new ideas for cost-effective ways to prevent rodents from burrowing into the earthen embankments of dams, canals, and levees. These burrows cause seepage paths in the embankment system which can lead to structural failures that endanger water supplies, cause property damage and endanger the lives of nearby populations. Many of the more traditional and “intuitive” methods have been tried with little success to date. We are hoping the Solver community can “dig deeper” than the rodents to find creative and effective solutions to this Challenge.
This Challenge requires only a written proposal.
Challenge Orientation Video
Subject matter experts from the Bureau of Reclamation and Boise Project Board of Control have provided this short video discussing the rodent burrows in earthen embankments problem: https://youtu.be/CY8TeSlT16o
This web site is hosted by a private entity and is not a service of the Bureau of Reclamation or the Department of the Interior (DOI). The solicitation and collection of your personal or individually identifiable information is subject to the host’s privacy and security policies and will not be shared with Reclamation or DOI unless you win the Challenge. Challenge winners’ personally identifiable information must be made available to Reclamation in order to collect an award. Please consult the Challenge Specific Agreement.
This Challenge is being conducted under the authority of the America COMPETES Reauthorization Act of 2010 (15 U.S.C. § 3719). The America COMPETES Reauthorization Act of 2010 states that awards for this Prize Competition may only be given to an individual that is a citizen or permanent resident of the United States, or an entity that is incorporated in and whose primary place of business is in the United States, subject to verification by the Seeker before Prizes are awarded. Further restrictions apply – see the Challenge Specific Agreement and the Federal Register Notice for full eligibility details.
Note: Submissions can be entertained from all Solvers regardless of whether they are U.S. citizens/entities. Meritorious submissions from non-eligible persons and entities, if any, will be recognized in publications issued by the Seeker announcing the results of the competition, such as press releases. However, prizes — whether monetary or otherwise — may not be awarded to non-eligible persons and under the authority of the America COMPETES Reauthorization Act of 2010 (15 USC 3719).
Source: InnoCentive Challenge ID: 9933763
The Seeker is looking to prevent the migration of an amine through a film under harsher than normal conditions (e.g. high temperature). Solutions could take the form of a film change/treatment, a substitute for the amine or anything else that could prevent migration without losing qualities of the product.
This Theoretical Challenge requires only a written proposal.
Source: InnoCentive Challenge ID: 9933909
Earlier this year, the American Heart Association (AHA), in partnership with Patient-Centered Outcomes Research Institute (PCORI), conducted a Challenge to hear patients' insights on how health decisions related to heart disease and stroke were made. After patients identified many areas of uncertainty, we are now turning to researchers and clinicians to address several of them through refinement into comparative effectiveness research questions that could benefit from precision medicine approaches. This is an Ideation Challenge with a guaranteed award for four submitters.
Source: InnoCentive Challenge ID: 9933836
Obstructive Sleep Apnea (OSA) affects millions of individuals in the United States and many more worldwide. Fortunately, an effective non-surgical treatment exists in the form of a continuous positive airway pressure (CPAP) device used while sleeping. Unfortunately, adherence to the use of a CPAP for people diagnosed with OSA lies in the 40-50% range despite past efforts to improve devices and educate patients. The Seeker is looking for innovative solutions for increasing adherence to CPAP treatment for OSA. Solutions may take a wide range of approaches to address the psychological, physical, or comfort issues faced by people who should be using a CPAP but are not.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Source: InnoCentive Challenge ID: 9933907
Aluminum sulfate Al2(SO4)3 is used as a coagulant in a water treatment process to obtain clarified water. The clarified water is further directed to demineralization (for feed boilers). While aluminum sulfate is effective in achieving the desired result, its use is associated with unacceptably high aluminum content in wastewater (> 0.04 mg/dm3 soluble aluminum). The Seeker for this Challenge is looking for an effective coagulant/process to cost-effectively treat the water without the negative side effect of high aluminum content in the effluent water.
Source: InnoCentive Challenge ID: 9933875
Recycled paper fibers from books, magazines, etc., are used to produce carton board. These waste fibers carry with them residues of hydrophobic adhesives – “stickies” – that tend to form lumps that cause disruptions in the board production line and defective goods, both with high economic consequences.
The Seeker is looking for new methods to prevent the formation of such lumps, either by removing the residual stickies or neutralizing their adhesive properties that cause the lumps.
This is a Reduction-to-Practice Challenge that requires submission of written documentation from the Solver. The Seeker will perform experimental validation of proposed solutions in order to determine the award.
Source: InnoCentive Challenge ID: 9933878
Current methods to recover sulfates from wastewater streams are limited in their capability to work in challenging industrial conditions and/or to generate a new revenue stream from the recovered sulfates. Hence, SUEZ is looking for a solution to solve these two limitations.
Source: InnoCentive Challenge ID: 9933861
Acne is a skin condition that is estimated to affect nearly 10% of people worldwide. Since the skin is highly visible to others, people with acne often suffer low self-esteem because of their appearance. Although treatments are available, patients struggle with demanding dosing regimens and low levels of efficacy, especially those with moderate to severe acne. Therefore, the Seeker is looking for novel treatment approaches to improve acne patients’ lives.
Source: InnoCentive Challenge ID: 9933873