Nearly 3 million people in the United States and 65 million people worldwide have epilepsy, a neurological condition which affects the nervous system and causes seizures. One in 26 people will develop epilepsy at some point in their lifetime, with 150,000 new cases annually in the United States. Nearly 80% of the people with epilepsy live in low- and middle-income countries and three-quarters of these individuals do not get the treatment they need.
Among those living with epilepsy, nearly one-third have ongoing seizures despite existing therapies. Each year, more than 1 out of 1,000 people with epilepsy die from sudden unexpected death in epilepsy (SUDEP). If seizures are uncontrolled, the risk of SUDEP increases to more than 1 out of 150. SUDEP is the leading cause of death in young adults with uncontrolled seizures.
In order to accelerate the identification of effective treatments for SUDEP, the Epilepsy Foundation SUDEP Institute is sponsoring a Reduction to Practice Challenge to develop a predictive biomarker or panel of biomarkers to identify people at risk for SUDEP or seizures that compromise cardiac or respiratory function. The biomarker(s) must serve as an endpoint or surrogate endpoint that will drive human SUDEP interventions. For example, the biomarker(s) may identify a high risk patient group that could be used to test existing candidate interventions such as seizure detection devices.
Milestone 1 requires a detailed Project Plan of the proposed solution. Milestone 2 involves the production of proof-of-concept data. Milestone 3 requires results that demonstrate the predictive efficacy of the biomarker(s). The SUDEP Institute intends to make up to 10 awards from a total award pool of $100,000 for Milestone 1, up to 4 awards of $25,000 each for Milestone 2, and a final award at least $800,000 for successful completion of Milestone 3.
A conditionally immortalized oligodendrocyte precursor cell line is required to advance research into therapies for multiple sclerosis (MS).
This is a Theoretical Challenge which requires a written proposal only. Awards will be made at the discretion of the Seeker after theoretical evaluation of the submissions. The Seeker retains the right to make partial awards should the awarded solution not meet all the Technical Requirements or Project Criteria. The Seeker wishes to engage successful Solvers to implement winning submissions and deliver cell lines in a second phase of this Challenge.
This Challenge sponsored by Scientists Without Borders is looking for low-cost, effective methods to fortify or supplement staple foods with folic acid for consumption by young women of child-bearing age in developing countries. Folic acid is critical for prevention of neural tube defects during pregnancy and for women's health overall.
The Seeker is looking for novel, unorthodox, and extraordinary opportunities for philanthropic investment. This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Read Challenge Details for Challenge 9780464
The Seeker requests novel biomarkers of response to the anti-angiogenic biologic therapy Bevacizumab. For this Theoretical Challenge, Solvers should provide pen and paper solutions describing their ideas for a biomarker.
The Seeker wishes understand potential models for sourcing and integrating reliable and validated regional food databases. Various food analysis databases exist, but the seeker requires models of how these may be networked or integrated to provide consolidated information that is useful to diabetes patients around the world who wish to balance their diet and insulin intake.
The goal of this Challenge sponsored by the Joseph H. Kanter Family Foundation is to generate innovative ideas for creating an activist network of patients, medical professionals, and the general public, focused on promoting a patient-centered learning health system in which decisions are informed by patient outcome data generated as a byproduct of delivering care.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
The Seeker wishes to identify an alternative urine marker, or a combination of markers, for the prediction of renal flares and prognosis in lupus nephritis. This is an Ideation Challenge with a guaranteed award of $ 10,000 USD.
Read Challenge Details for Challenge 9701396
The Seeker is looking for novel, breakthrough, therapeutic concepts in the field of oncology. This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Read Challenge Details for Challenge 9701378
The Seeker is looking for an innovative approach or several simultaneous approaches to identify compounds and prophylactic interventions that could be developed into new therapeutics or treatments which would provide enhanced protection against organophosphorus pesticide (OP) poisoning.
Read Challenge Details for Challenge 9668668