Nearly 3 million people in the United States and 65 million people worldwide have epilepsy, a neurological condition which affects the nervous system and causes seizures. One in 26 people will develop epilepsy at some point in their lifetime, with 150,000 new cases annually in the United States. Nearly 80% of the people with epilepsy live in low- and middle-income countries and three-quarters of these individuals do not get the treatment they need.
Among those living with epilepsy, nearly one-third have ongoing seizures despite existing therapies. Each year, more than 1 out of 1,000 people with epilepsy die from sudden unexpected death in epilepsy (SUDEP). If seizures are uncontrolled, the risk of SUDEP increases to more than 1 out of 150. SUDEP is the leading cause of death in young adults with uncontrolled seizures.
In order to accelerate the identification of effective treatments for SUDEP, the Epilepsy Foundation SUDEP Institute is sponsoring a Reduction to Practice Challenge to develop a predictive biomarker or panel of biomarkers to identify people at risk for SUDEP or seizures that compromise cardiac or respiratory function. The biomarker(s) must serve as an endpoint or surrogate endpoint that will drive human SUDEP interventions. For example, the biomarker(s) may identify a high risk patient group that could be used to test existing candidate interventions such as seizure detection devices.
Milestone 1 requires a detailed Project Plan of the proposed solution. Milestone 2 involves the production of proof-of-concept data. Milestone 3 requires results that demonstrate the predictive efficacy of the biomarker(s). The SUDEP Institute intends to make up to 10 awards from a total award pool of $100,000 for Milestone 1, up to 4 awards of $25,000 each for Milestone 2, and a final award at least $800,000 for successful completion of Milestone 3.
The Seeker wishes understand potential models for sourcing and integrating reliable and validated regional food databases. Various food analysis databases exist, but the seeker requires models of how these may be networked or integrated to provide consolidated information that is useful to diabetes patients around the world who wish to balance their diet and insulin intake.
The goal of this Challenge sponsored by the Joseph H. Kanter Family Foundation is to generate innovative ideas for creating an activist network of patients, medical professionals, and the general public, focused on promoting a patient-centered learning health system in which decisions are informed by patient outcome data generated as a byproduct of delivering care.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
The Seeker wishes to identify an alternative urine marker, or a combination of markers, for the prediction of renal flares and prognosis in lupus nephritis. This is an Ideation Challenge with a guaranteed award of $ 10,000 USD.
Read Challenge Details for Challenge 9701396
The Seeker is looking for novel, breakthrough, therapeutic concepts in the field of oncology. This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Read Challenge Details for Challenge 9701378
The Seeker is looking for an innovative approach or several simultaneous approaches to identify compounds and prophylactic interventions that could be developed into new therapeutics or treatments which would provide enhanced protection against organophosphorus pesticide (OP) poisoning.
Read Challenge Details for Challenge 9668668
NASA, USAID, Department of State, and NIKE joined together to host LAUNCH in an effort to identify, showcase and support innovative approaches to sustainability challenges through a series of forums. LAUNCH searches for visionaries, whose world-class ideas, technologies or programs show great promise for making tangible impacts on society. Through the next Launch series, ten innovators and 40 thought leaders will come together to address an issue that affects every human: health.
Sustaining quality of life on Earth and in space requires transformative advances in science and technology, along with new models, policies and behaviors that will guide human development. The search for innovative technology solutions to ensure healthy astronauts orbiting the planet mirrors healthcare challenges faced by providers throughout the world. The same requirements for simple, rugged, ultra portable, low power devices to provide remote diagnostic capability serves dual needs for humans living within the extreme environments on and off the planet. Targeting preventative health measures within the first twenty years of life offers a unique opportunity to change the human condition for this and future generations.
LAUNCH seeks innovations that are preventive with a focus on nutrition, exercise, and health care Specifically, LAUNCH is seeking innovations in providing and improving:
Optimal nutrition (access, choice, and quality of nutritious food and required nutrients)
Regular participation in physical activity and healthy lifestyle choices.
Participation in primary preventive health care including supporting infrastructure, such as diagnostic and monitoring technology
The Chordoma Foundation requests cell lines or animal models that can be used for research into chordoma - a slow growing bone cancer that is often resistant to radio- and chemotherapies.
This Challenge has now been opened to include animal models and the deadline has been changed to a 3 month rolling deadline. This innoCentivee Challenge will close once the Seeker has 3 submissions to evaluate, but the Chordoma Foundation will continue to incentivize research into Chordoma and potential therapies.
This Challenge requires suggestions for biomarkers predictive of Progressive Multifocal Luekoencephalopathy (PML).
This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker. The Seeker reserves the right to make partial awards to Solvers in exchange for non-exclusive rights.
Read Challenge Details for Challenge 9522323
An animal model is required which allows replication of JC virus. The Seeker requires a theoretical proposal with a detailed strategy how to step-wise develop and test the animal model. A non-human cell-culture/tissue model allowing JC virus replication would also be considered.
Successful Solvers exhibiting sufficient knowledge and ability may be asked to enter a contract research agreement with the Seeker to develop such an animal model. This is a Theoretical Challenge and requires only a pen & paper solution.
Read Challenge Details for Challenge 9435248
The Seeker wishes to identify conductive materials feasible for use in a reference electrode. The material should be suitable for in vivo physiological measurements.
This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker.
Read Challenge Details for Challenge 9314866