Nearly 3 million people in the United States and 65 million people worldwide have epilepsy, a neurological condition which affects the nervous system and causes seizures. One in 26 people will develop epilepsy at some point in their lifetime, with 150,000 new cases annually in the United States. Nearly 80% of the people with epilepsy live in low- and middle-income countries and three-quarters of these individuals do not get the treatment they need.
Among those living with epilepsy, nearly one-third have ongoing seizures despite existing therapies. Each year, more than 1 out of 1,000 people with epilepsy die from sudden unexpected death in epilepsy (SUDEP). If seizures are uncontrolled, the risk of SUDEP increases to more than 1 out of 150. SUDEP is the leading cause of death in young adults with uncontrolled seizures.
In order to accelerate the identification of effective treatments for SUDEP, the Epilepsy Foundation SUDEP Institute is sponsoring a Reduction to Practice Challenge to develop a predictive biomarker or panel of biomarkers to identify people at risk for SUDEP or seizures that compromise cardiac or respiratory function. The biomarker(s) must serve as an endpoint or surrogate endpoint that will drive human SUDEP interventions. For example, the biomarker(s) may identify a high risk patient group that could be used to test existing candidate interventions such as seizure detection devices.
Milestone 1 requires a detailed Project Plan of the proposed solution. Milestone 2 involves the production of proof-of-concept data. Milestone 3 requires results that demonstrate the predictive efficacy of the biomarker(s). The SUDEP Institute intends to make up to 10 awards from a total award pool of $100,000 for Milestone 1, up to 4 awards of $25,000 each for Milestone 2, and a final award at least $800,000 for successful completion of Milestone 3.
Markers predictive of placebo-responders in clinical drug trials, or rational for improved trial designs, are required in order to increase the efficacy of clinical drug trials and better understand the effects of human therapies.
This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker.
Read Challenge Details for Challenge 9188486
The Rockefeller Foundation is providing support to this Seeker for the design of a low cost water treatment system based on solar radiation and titanium dioxide (TiO2). It is part of the Global Giveback Innovation Challenge Set. A prototype design will be required using known proven technology supplied by the Seeker.
Read Challenge Details for Challenge 9182887
This Challenge is asking InnoCentive Solvers to formulate well-defined problems aimed at advancing our knowledge about Type 1 Diabetes and ultimately eradication of the disease. This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Read Challenge Details for Challenge 9145306
The Drugs for Neglected Diseases initiative (DNDi), is looking for potential drug targets for kinetoplastid infectious diseases affecting the developing world (African Sleeping Sickness, Visceral Leishmaniasis, Cutaneous Leishmaniasis, and Chagas Disease). The focus is on chemically validated targets and associated small molecules.
The Rockefeller Foundation is providing support to this Seeker for the design of a new rainwater harvesting storage tank for use in a wetland Region in India. It is part of the Global Giveback Innovation Challenge Set. The tank needs to be affordable by the local people and have a capacity of 6000 liters. High water table, flooding, differential settlement and acidic soil are just some of the issues to be overcome with the proper design.
Read Challenge Details for Challenge 9097564
We are searching for an aircraft interior space sampling and analysis methodology to determine if aircraft interior is at or below a cleanliness standard for contagious diseases. We would like to gather ideas on what, where and how to sample as well as methods of analysis that could be fast and as simple as possible.
This is an Ideation Challenge so your creativity and experience qualify you to participate in this Challenge. Responses are expected (but not limited) to be about 2-3 written pages not including figures. You do not have to meet every requirement to be eligible for an award. A good solid answer that is part of the solution would still be considered.
Read Challenge Details for Challenge 8838485
Surveying and maintaining the safety of air in crowded, public spaces is extremely important for public health. Areas in which large numbers of people spend extended amounts of time, such as airplanes, buses, subway stations, etc. must be carefully monitored to ensure that any communicable disease outbreaks (e.g. Swine Flu) or natural or manmade threats are detected and addressed rapidly.
This Challenge is seeking new ideas for methods of detecting pathogens within an airplane cabin environment. The Seeker is looking for novel ideas for platform technologies that they may be able to be used for this purpose. The pathogens of interest include dangerous biological agents, such as bacteria and viruses. Ideally a single platform could be used to detect all such airborne pathogens, but it’s possible that some platforms may only operate effectively for one or a few applications.
This Challenge is looking for novel inhibitors of proteases and lipases. This is a Reduction-to-Practice Challenge that requires a written proposal and experimental proof-of-concept data.
Read Challenge Details for Challenge 8740549
Identification of a water-related problem in developing countries that can be the basis of an upcoming InnoCentive Challenge. Problems must be actionable and relatively low cost.
Read Challenge Details for Challenge 8652749
This challenge is looking for a method of identification and quantification of specific Lactobacillus strains in clinical samples. This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Read Challenge Details for Challenge 8534503