Nearly 3 million people in the United States and 65 million people worldwide have epilepsy, a neurological condition which affects the nervous system and causes seizures. One in 26 people will develop epilepsy at some point in their lifetime, with 150,000 new cases annually in the United States. Nearly 80% of the people with epilepsy live in low- and middle-income countries and three-quarters of these individuals do not get the treatment they need.
Among those living with epilepsy, nearly one-third have ongoing seizures despite existing therapies. Each year, more than 1 out of 1,000 people with epilepsy die from sudden unexpected death in epilepsy (SUDEP). If seizures are uncontrolled, the risk of SUDEP increases to more than 1 out of 150. SUDEP is the leading cause of death in young adults with uncontrolled seizures.
In order to accelerate the identification of effective treatments for SUDEP, the Epilepsy Foundation SUDEP Institute is sponsoring a Reduction to Practice Challenge to develop a predictive biomarker or panel of biomarkers to identify people at risk for SUDEP or seizures that compromise cardiac or respiratory function. The biomarker(s) must serve as an endpoint or surrogate endpoint that will drive human SUDEP interventions. For example, the biomarker(s) may identify a high risk patient group that could be used to test existing candidate interventions such as seizure detection devices.
Milestone 1 requires a detailed Project Plan of the proposed solution. Milestone 2 involves the production of proof-of-concept data. Milestone 3 requires results that demonstrate the predictive efficacy of the biomarker(s). The SUDEP Institute intends to make up to 10 awards from a total award pool of $100,000 for Milestone 1, up to 4 awards of $25,000 each for Milestone 2, and a final award at least $800,000 for successful completion of Milestone 3.
The Seeker is looking for a comprehensive review of the history of Lupus drug development along with actionable recommendations on how this process could be improved. This is a Theoretical Challenge that requires only a written proposal to be submitted.
Read Challenge Details for Challenge 8321563
Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease) is a fatal neurodegenerative disorder characterized by selective death of motor neurons in the brain and spinal cord. This leads to muscle weakness, atrophy, and gradual paralysis. At present, there is no effective therapy for the disease and patients usually die within 2-5 years after the onset of symptoms. In order to accelerate the identification of effective treatments for ALS, a biomarker for measuring disease progression is needed.
Read Challenge Details for Challenge 8305421
We are searching for an aircraft pre-boarding passenger screening system that would indicate exposure to or infection by a contagious agent. The pre-clinical, pre-symptomatic medical diagnostic system must be non-invasive to the greatest extent possible. There should be no need for body fluids extraction (i.e. it can be detected from skin, breath, etc.)
Read Challenge Details for Challenge 8257333
The Seeker is looking for a method for counting the number of times an object has been sterilized. This is a Theoretical Challenge that requires only a written proposal to be submitted.
Read Challenge Details for Challenge 8222838
EnterpriseWorks/VITA (EWV), is seeking design ideas for a low-cost rain water storage system that can be installed in households in developing countries. The solution is expected to facilitate access to clean water at a household level, addressing a problem that affects millions of people worldwide who are living in impoverished communities or rural areas where access to clean water is limited. Domestic rain water harvesting is a proven technology that can be a valuable option for accessing and storing water year round. However, the high cost of available rain water storage systems makes them well beyond the reach of low-income families to install in their homes.
A solution to this problem would not only provide convenient and affordable access to scarce water resources, but would also allow families, particularly the women and children that are usually tasked with water collection, to spend less time walking distances to collect water and more time on activities that can bring in income and improve the quality of life.
Read Challenge Details for Challenge 7497318
The challenge is looking for novel ideas and technologies that can be applied to achieve fast detection and identification of viable microorganisms and determination of antibiotic susceptibility which will enable faster diagnosis of infections caused by bacteria, for example sepsis and tuberculosis, and lead to more effective therapy and better patient outcomes.
Our Seeker Client, FasterCures, a nonprofit organization, is looking for novel approaches/incentives that can reduce the first-mover disadvantage and induce companies to invest more in biomarkers research and qualification, while not limiting their availability to others.
Read Challenge Details for Challenge 7273006
The Seeker is looking for a comprehensive approach - perhaps using some data mining tools involving classification and regression trees, cluster analysis, etc. – for each of two related problems. Both problems involve analyzing a wide range of covariates that may help (a) identify sub-groups of patients who have a differential response to treatment, and (b) predict responders and non-responders in clinical trials.