Nearly 3 million people in the United States and 65 million people worldwide have epilepsy, a neurological condition which affects the nervous system and causes seizures. One in 26 people will develop epilepsy at some point in their lifetime, with 150,000 new cases annually in the United States. Nearly 80% of the people with epilepsy live in low- and middle-income countries and three-quarters of these individuals do not get the treatment they need.
Among those living with epilepsy, nearly one-third have ongoing seizures despite existing therapies. Each year, more than 1 out of 1,000 people with epilepsy die from sudden unexpected death in epilepsy (SUDEP). If seizures are uncontrolled, the risk of SUDEP increases to more than 1 out of 150. SUDEP is the leading cause of death in young adults with uncontrolled seizures.
In order to accelerate the identification of effective treatments for SUDEP, the Epilepsy Foundation SUDEP Institute is sponsoring a Reduction to Practice Challenge to develop a predictive biomarker or panel of biomarkers to identify people at risk for SUDEP or seizures that compromise cardiac or respiratory function. The biomarker(s) must serve as an endpoint or surrogate endpoint that will drive human SUDEP interventions. For example, the biomarker(s) may identify a high risk patient group that could be used to test existing candidate interventions such as seizure detection devices.
Milestone 1 requires a detailed Project Plan of the proposed solution. Milestone 2 involves the production of proof-of-concept data. Milestone 3 requires results that demonstrate the predictive efficacy of the biomarker(s). The SUDEP Institute intends to make up to 10 awards from a total award pool of $100,000 for Milestone 1, up to 4 awards of $25,000 each for Milestone 2, and a final award at least $800,000 for successful completion of Milestone 3.
The aim of the Conquer Paralysis Now (CPN) Challenge is to accelerate the development of treatments for spinal cord injury (SCI) in order to provide significant improvements in patients’ quality of life. We want to help SCI patients carry out every day functions unaided that we take for granted like showering, walking or eating.
The second round of Stage I has just been launched to provide seed funding to a wide range of non-traditional approaches. In Stage I of the Challenge, we are offering 12 grants of at least $50,000 across our 6 award categories. These grant awards want to attract SCI research from new investigators, collaborators, out of the box thinkers and experts from adjacent fields among others.
Applicants are invited to submit their proposals until January 21st, 2016. Please note that Applicants CANNOT submit proposals for more than one grant award.
In humanitarian emergencies such as flooding, epidemics, and conflicts, there is a rapid demand for health facilities and therefore also for medical waste management. Temporary burners or small-scale incinerators are usually constructed to deal with the burnable medical waste. However these incinerators often don’t reach sufficiently high temperatures for the necessary duration, are inefficient in terms of fuel consumption and heat retention, and have short lifespans. The higher performing designs can be difficult to construct and operate without specially trained workers, or specialized materials/parts that can take time to source. The Seeker desires a simple, efficient, and durable incinerator that is safe to operate and affordable in low-middle income countries. The design must be lightweight and easy to transport and assemble, or built on-site with accessible skills and materials.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in young adults who have epilepsy and poorly controlled seizures. Each year, more than 1 out of 1,000 people with epilepsy die from SUDEP, and, if seizures are uncontrolled, the risk increases to more than 1 out of 150. Unfortunately, one-third of people living with epilepsy are faced with ongoing seizures despite all currently available therapies. Individuals who have frequent generalized tonic-clonic seizures appear to be at highest risk.
A widespread lack of awareness and ongoing fear and discrimination lead many individuals to hide their epilepsy and to accept ongoing seizures instead of seeking out more effective treatments. Additionally, because they do not understand that epilepsy can be life threatening, many do not adhere to their treatment plan to obtain complete seizure control – which is zero seizures. Many individuals with epilepsy may not achieve maximal seizure control because of lack of access to best therapies, poor adherence to prescribed therapies, or lifestyle factors that may provoke seizures. These circumstances and behaviors increase their risk of continued seizures, injuries, and SUDEP.
The Epilepsy Foundation SUDEP Institute is challenging Solvers to come up with ideas for a method/intervention to reduce the risk of seizures, especially convulsive or tonic-clonic seizures, with the purpose of preventing SUDEP. Can you help us create a tool to empower more people with epilepsy to improve seizure control?
Access to safe, clean and reliable sources of energy has a significant impact on health, quality of life, education and economic productivity. Particularly in the developing world, access to such type of energy has the potential to change the landscape in terms of poverty, exclusion, gender inequality, and, no less important, global warming.
Liquefied Petroleum Gas (LPG) is a clean-burning, portable, and efficient fuel that is increasingly used in many developing countries. However, the existence of a large number of aging cylinders constitutes a worrying safety hazard due to lack of maintenance that puts populations in danger and ultimately hinders the growth of a successful LPG market.
Hence, the Seeker to this Challenge is looking for high-value alternative uses for substandard cylinders, so that they can be recycled and removed from the LPG distribution channels.
Engage in this Challenge and contribute to save lives and promote clean energy uptake throughout Africa!
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in young adults who have epilepsy and cannot control their seizures. Each year, more than 1 out of 1,000 people with epilepsy die from SUDEP, and, if seizures are uncontrolled, the risk increases to more than 1 out of 150.
A widespread lack of awareness and ongoing fear and discrimination lead too many individuals to hide their epilepsy and to accept ongoing seizures instead of seeking out more effective treatments. This increases their risk of SUDEP.
The Epilepsy Foundation SUDEP Institute is determined to change this and is challenging Solvers to come up with ideas for a creative advocacy campaign that encourages people with seizures and epilepsy to seek optimal seizure control and to educate themselves and their families about SUDEP and how they can mitigate its risks. In addition, the campaign should invite the broader health care community to talk about SUDEP, understand the importance of not accepting ongoing seizures, and pursue all effective treatment options.
Can you help us to demystify seizures and epilepsy, and empower people with epilepsy?
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
In the Southern Indian state of Tamil Nadu, 5 phones exist for every 2 toilets. Even in areas with toilets, a lack of education and understanding about proper use has led to 60% of the population practicing open defecation. As a key factor in debilitating health and social inflictions, open defecation is one of the facets that has resulted in an infant mortality rate of 36/1000 (a fifth of these deaths from sanitation related illnesses). This Challenge requires Solvers to present their ideas for a mobile phone game which can educate 5-14 year old children about better hygiene practices and persuade them to instinctively use sanitation facilities rather than defecate in the open.
This is a Theoretical Challenge that requires only the submission of a completed application form.
The current spinal cord injury (SCI) research community tend to publish scientific studies with ‘significant’ results and not studies that seem uneventful. Nevertheless, we can learn as much from ‘negative’ results as we can from ‘positive’ ones. Lessons learned from research help to minimize the duplication of experiments and narrow down pathways of innovation. It may also lead to the generation of novel ideas to tackle the same problem. The goal of this platform is to foster the publication of research in an easily accessible format, which scientists would have been hesitant to reveal in normal circumstances. This will help ensure that the total amount of money allocated to SCI research, both inside and outside the Challenge Program, is more efficiently spent. The prize will also provide a good forum to facilitate improved information-sharing and collaboration, as researchers will be able to review and comment on each other’s research.
After a 6-month period, to allow users enough time to register and come to terms with the Trial & Error concept, the top publication from each quarter will receive $1,500, the second $1,000 and the third $500.
The aim of the Conquer Paralysis Now (CPN) Challenge is to accelerate the development of treatments for spinal cord injury (SCI) in order to provide significant improvements in patients’ quality of life. We want to help SCI patients carry out every day functions unaided that we take for granted like showering, walking or eating. Stage I has just been launched to provide seed funding to a wide range of non-traditional approaches and will recur annually for the next six years. In Stage I of the Challenge, we are offering at least 2 grants of $50,000 in each of our 6 categories. These grant awards want to attract SCI research from new investigators, collaborators, out of the box thinkers and experts from adjacent fields among others.
Applicants are invited to submit their proposals until April 1st, 2015. Please note that Applicants CANNOT submit proposals for more than one grant award.
Fun, creative and simple campaigns are extremely effective in catching people’s attention and raising awareness to health conditions. From patients to healthcare professionals, the whole population can gather around a cause and engage with the movement, creating a global viral effect that builds awareness, educates and informs people towards improved health – for example, who is not aware of what a moustache in November means?
The Seeker to this Challenge is asking you to create an inspirational, fun, and engaging global movement to help improving skin health, a global concern that affects the lives of millions of people. Can you come up with the next global health movement?
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
DARPA (Defense Advanced Research Projects Agency) seeks methods to accurately forecast the spread of chikungunya virus in the Caribbean, and North, Central, and South America.
This Challenge has a special award structure with awards of $150,000 and $100,000 for the top two overall Solvers and four honorable mention awards of $50,000 each. In addition, top Solvers in each Methodology Category (data, robustness, applicability, presentation, and computation) may win $10,000. The top six overall Solvers will be invited to DARPA for the Program Finale Meeting where they will participate in an interactive meeting to share best practices, collaborate, and facilitate continuing Solver community cohesion.
This is a Reduction-to-Practice Challenge that requires written documentation and multiple submissions of forecasts for the virus’ spread. Additionally, as a Prodigy Challenge an online leaderboard will be available to track Solver performance.
This web site is hosted by a private entity and is not a service of the Defense Advanced Research Projects Agency (DARPA) or the Department of Defense (DoD). The solicitation and collection of your personal or individually identifiable information is subject to the host’s privacy and security policies and will not be shared with DARPA or the DoD unless you win the Challenge. Challenge winners’ personally identifiable information must be made available to DARPA in order to collect an award. Please consult the Challenge Specific Agreement.