A request for various non-commercial chemical compounds, proteins, extracts, polymers, and DNA sequences linked by a common sub-structure, property, origin, or biological activity. Seekers use these Challenges to investigate structure-activity relationships, obtain novel intermediates, expand library diversity, and so on. Solvers submit structures they have or are willing to make, and Seekers choose those of interest. Solvers receive a modest award in exchange for delivery of the compound and non-exclusive rights for the Seeker to use the compound internally. Solvers may receive a much larger award in the future if the Seeker decides that they desire exclusive IP rights to the compound.