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Mechanisms of Action of Preservative Boosters in Bacteria

22 Submissions
$20,000 USD
Challenge closed

Challenge overview

A deep mechanistic understanding of the action of chelating agents in controlling microbial growth, especially in combination with antibacterial agents, is needed. The Seeker requests detailed insights regarding the action of chelating agents, such as ethylenediamine tetraacetate (EDTA), in increasing the sensitivity of bacteria to a variety of antibacterial agents and suggested paths for identifying alternative chelating agents, or alternatives to use of chelating agents.

This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker.
The Seeker believes that a better understanding of microbes will help them to develop more environmentally sustainable preservative systems or to produce better formulated consumer products that rely less on preservatives.

A deep mechanistic understanding of the action of chelating agents as microbial control tools is needed, especially in combination with antibacterial agents. The Seeker requests detailed insights regarding the action of chelating agents, such as ethylenediamine tetraacetate (EDTA) in increasing the sensitivity of bacteria to a variety of antibacterial agents and suggested paths for identifying alternative chelating agents. Alternatively, strategies for reducing the required amount of chelating agent or alternatives to their use are welcomed by the Seeker.

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