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Regio- and stereocontrolled tricyclic alcohols

$5,000 USD
Challenge closed

Challenge overview

Please provide a flexible retrosynthetic analysis that will allow convenient access to defined regio- and stereochemical isomers of this tricyclic alcohol. These molecules may have been previously reported in the literature, but the existing route may be lengthy, expensive, and low yielding. Devise the 'best' synthetic pathway. The following tricyclic alcohols are in need of an efficient, regio-, and stereodefined synthetic strategy. We are seeking a novel and convergent synthetic route which will allow for the efficient preparation of all 6 regio and stereoisomers from readily available raw materials. The synthetic route must be amenable to production on the multi gram scale. Please provide a detailed description of your synthetic pathway with the supporting literature procedures employed.

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