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Seeking Inhibitors of Mammalian Oxidosqualene Cyclase (a.k.a. Lanosterol Synthase)

1 Submissions
Challenge closed

Challenge overview

Material supply of compounds which are inhibitors of mammalian oxidosqualene cyclase (a.k.a. lanosterol synthase or squalene epoxide synthase) is desired.  Potential structures which meet this requirement are provided in the Detailed Description of this Challenge.  The Seeker intends to award multiple Solvers for each of their qualifying submissions. 

Building Block Challenge:  In order to submit to this Challenge, you must allow the Seeker to view the structure of your compound in the Structure Selection stage of the Challenge. 

Intellectual Property:  In return for the Initial Transfer Fee of $200 per compound, you are expected to grant the Seeker only a non-exclusive license to test your compound(s) in their in-house assays and/or use the compound(s) to prepare other compounds for in-house testing.

 

Material supply of non-commercial compounds which are inhibitors of mammalian oxidosqualene cyclase (a.k.a. lanosterol synthase or squalene epoxide synthase) is desired.  Potential structures which meet this requirement are provided in the Detailed Description of this Challenge.   The Seeker intends to award multiple Solvers for each of their qualifying submissions. 

By the deadline, Solvers are requested to provide a list of structures which meet the Requirements listed in the Detailed Description of the Challenge. For the structures that are selected by the Seeker, the Solver shall then send in material samples along with documentation of their purity. 

Referral Award:  If you refer a new Solver to this Challenge and he or she receives an award for the Challenge, you will receive an award equal to 10% of what your referred Solver received. 

Please go to our Upload Your Libraries Challenge if you would like to have your list of compounds for this Challenge considered for future Challenges, or if you would like to upload your entire library of compounds for consideration in future Challenges. 

This Challenge is targeting Solvers who: 

  • have matching compounds already made (on the shelf), or;
  • are ready to synthesize matching compounds within the provided timelines.

This Challenge provides Solvers with a three month time period for preparing the selected compounds after the deadline of the Challenge.

Use the slider to explore how the Challenge process works:

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